Mg2+-ATP Sensing in CNNM, a Putative Magnesium Transporter
نویسندگان
چکیده
منابع مشابه
Mg2+-sensing mechanism of Mg2+ transporter MgtE probed by molecular dynamics study.
Proper regulation of the intracellular ion concentration is essential to maintain life and is achieved by ion transporters that transport their substrates across the membrane in a strictly regulated manner. MgtE is a Mg(2+) transporter that may function in the homeostasis of the intracellular Mg(2+) concentration. A recent crystallographic study revealed that its cytosolic domain undergoes a Mg...
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The MM281 strain of Salmonella typhimurium which possesses mutations in each its three known Mg2+ transport systems and requires 100 mM Mg2+ for growth was used to screen a genomic library from the gram-positive alkaliphilic bacterium Bacillus firmus OF4 for clones that could restore the ability to grow without Mg2+ supplementation. Of the clones obtained, five also conferred sensitivity to Co2...
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Magnesium (Mg2+) is indispensable for many physiological processes in the cell impacting organ function (de Baaij et al. 2015). Intracellular concentrations of free Mg2+ aremaintained within a narrow range (0.5–1.2 mM) through tightly regulated Mg2+ influx and effluxmechanisms (Ebel & Gunther, 1980). InhibitionofMg2+ effluxby substitution of extracellular Na+ by choline in mammalian cells indic...
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Effects of ATP and Mg2+ concentrations on bioluminescence reaction of luciferase (Photinus pyralis) were investigated by home-made luminometer. The Michaelis constants of the enzyme for ATP and Mg2+ obtained from the Lineweaver-Burk graph, were 61.9 mM ±3.3 mM and 251.6mM ± 39.0mM...
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The ATP-binding cassette (ABC) protein superfamily constitutes one of the largest protein families known in plants. In this report, we performed a complete inventory of ABC protein genes in Vitis vinifera, the whole genome of which has been sequenced. By comparison with ABC protein members of Arabidopsis thaliana, we identified 135 putative ABC proteins with 1 or 2 NBDs in V. vinifera. Of these...
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ژورنال
عنوان ژورنال: Structure
سال: 2020
ISSN: 0969-2126
DOI: 10.1016/j.str.2019.11.016